| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4314152 | Behavioural Brain Research | 2010 | 5 Pages |
Abstract
The objective of this study was to evaluate basic behavioural phenotypes and methamphetamine-induced hyperactivity in dopamine transporter (DAT) knockdown and control mice after local injections of small interference RNA into ventral tegmental area/substantia nigra once every other day for 14 days. Local knockdown of DAT expression in the mouse brain did not affect basic behavioural functions, but these mice displayed elevated depression-like immobility and a ∼35% reduction of methamphetamine-induced hyperactivity.
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Authors
Yao-Chu Chen, Wen-Sung Lai,