| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4314262 | Behavioural Brain Research | 2010 | 5 Pages |
Abstract
The role of amygdaloid glutamatergic receptors (GluRs) in maintenance of the sensory versus emotional component of neuropathic pain was studied by assessing monofilament-induced limb withdrawal response (sensory pain) and aversive place-conditioning behavior (emotional pain) following amygdaloid administration of various glutamatergic compounds in nerve-injured animals. The results indicate that endogenous activation of amygdaloid group I metabotropic GluRs, mGluR1 and mGluR5, and the NMDA-R contributes to maintenance of sensory and emotional components of neuropathic pain. The predominant effect by amygdaloid group I mGluRs was facilitation of emotional-like pain behavior.
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Authors
Osei B. Ansah, Nora Bourbia, Leonor Gonçalves, Armando Almeida, Antti Pertovaara,