Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4314539 | Behavioural Brain Research | 2009 | 4 Pages |
Abstract
The opiate-receptor antagonist naloxone was administered to rats after passive-avoidance training either alone or in combination with forced-swim stress. A retention test revealed that while naloxone enhanced retention when administered alone, it impaired retention when administered in combination with forced-swim stress. The findings provide evidence for a “protective” endogenous opioid-based system that, when not blocked pharmacologically, limits enhancement or impairment of retention under conditions of mild and intense stress, respectively.
Related Topics
Life Sciences
Neuroscience
Behavioral Neuroscience
Authors
Allen M. Schneider, Peter E. Simson, Krista Spiller, Jonathan Adelstein, Amanda Vacharat, Kenneth R. Short, Lynn G. Kirby,