Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4314707 | Behavioural Brain Research | 2009 | 5 Pages |
Abstract
Aged heterozygous Rolling Nagoya mice carrying Cav2.1α1 mutation show deficits with regard to spatial short-term memory using hippocampus-related object location test, but not with regard to nonspatial memory using perirhinal cortex-related object recognition test. In hippocampus, wild-type Cav2.1α1 mRNA exhibited lower expression and mutant-type expression was higher in aged heterozygous mice. In perirhinal cortex, there were no significantly different expressions. Alteration of age-dependent expressions of Cav2.1 channels differs in different regions with related effects on behavioral performances.
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Authors
Eiki Takahashi, Kimie Niimi, Chitoshi Itakura,