Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4314835 | Behavioural Brain Research | 2009 | 4 Pages |
Abstract
Flunitrazepam has been reported to trigger cases of extreme violence in man and recently it was shown to heighten aggression in experimental rats. The underlying mechanisms may involve disinhibited/impulsive behavior.Here, tolerance developed to the behavioral disinhibiting effect of flunitrazepam in Vogel's drinking conflict model, both in rats treated with flunitrazepam (0.32 mg/kg/day) for three weeks, as well as in rats treated for six weeks (0.32 mg/kg/day three weeks + 0.56 mg/kg/day three weeks).The results suggest that behavioral disinhibition is of limited importance in the mechanisms underlying the pro-aggressive effect of chronic flunitrazepam administration.
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Authors
Anders I. Svensson,