Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4315459 | Behavioural Brain Research | 2008 | 6 Pages |
Abstract
We investigated the effects of anisomycin (ANI) treatment (150Â mg/kg s.c.) during late stages of memory consolidation in a juvenile recognition task in mice. ANI treatment blocked 24Â h recognition memory if administered 9Â h, 12Â h or 15Â h after learning. As shown by a significantly reduced incorporation of radioactively labelled amino acids into newly synthesized proteins, translational arrest by ANI treatment lasted for 3-4Â h, thus covering the complete time period between 9Â h and 18Â h after memory acquisition. Together with previous findings [Richter K, Wolf G, Engelmann M. Social recognition memory requires two stages of protein synthesis in mice. Learn Mem 2005;12(4):407-13], our data suggest two distinct stages of protein synthesis to occur during the first 24Â h after learning: an early, relatively short-stage, starting immediately after learning and lasting for approximately 3Â h, and a second stage starting 6Â h after learning lasting for approximately 12Â h. This is the first report of such a long-lasting protein synthesis-dependent second consolidation phase in mice and suggests that long-term consolidation of juvenile recognition memory comprises multiple waves of protein synthesis and complex cascades of inter- and intra-cellular signaling processes.
Related Topics
Life Sciences
Neuroscience
Behavioral Neuroscience
Authors
Klaus Wanisch, Carsten T. Wotjak, Mario Engelmann,