Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4315596 | Behavioural Brain Research | 2007 | 5 Pages |
Abstract
Whether the δ-opioid receptor (DOR) system can modulate behavioral effects of cocaine remains equivocal. We examined whether site- and subtype-selective blockade of DORs within the rat mesocorticolimbic system affects cocaine self-administration. The DOR antagonist naltrindole 5â²-isothiocyanate (5â²-NTII; 5 nmol) was microinjected into the nucleus accumbens (NAcc), ventral tegmental area (VTA), or amygdala (AMYG) in rats self-administering 1.5 mg/kg cocaine under a progressive ratio (PR) schedule. Intra-NAcc 5â²-NTII significantly decreased cocaine self-administration, while 5â²-NTII administration into the VTA significantly increased cocaine-maintained responding. 5â²-NTII administration into the AMYG produced no effect. These data support a site-specific role of DORs in cocaine's behavioral effects.
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Authors
Sara Jane Ward, David C.S. Roberts,