Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4315993 | Behavioural Brain Research | 2007 | 4 Pages |
Abstract
Deficient sensorimotor gating, measured as prepulse inhibition (PPI) of startle, reflects disturbed information processing found in neuropsychiatric disorders. Examining the ability to selectively breed rats for high and low PPI, results showed significant differences of PPI scores within two generations. Comparing antipsychotics to restore PPI of the low group, haloperidol was shown more effective than clozapine. This suggests low PPI rats may be useful models for neuropsychiatric disorders and screening antipsychotics.
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Authors
Martin Hadamitzky, Silke Harich, Michael Koch, Kerstin Schwabe,