Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4316026 | Behavioural Brain Research | 2006 | 4 Pages |
Abstract
The effects of extracts of Crocus sativus L. (CSE), on memory were investigated in the rat by using the object recognition and the step-through passive avoidance task. In the first study, post-training administration of CSE (30 and 60Â g/kg) successfully counteracted extinction of recognition memory in the normal rat, suggesting that CSE modulates storage and/or retrieval of information. In a subsequent study, pre-training treatment with CSE (30 and 60Â mg/kg) significantly antagonized the scopolamine (0.75Â mg/kg)-induced performance deficits in the step-through passive avoidance test. These results support and extend prior findings about the implication of CSE in learning and memory mechanisms.
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Authors
Nikolaos Pitsikas, Nikolaos Sakellaridis,