| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4316324 | Behavioural Brain Research | 2006 | 7 Pages |
Abstract
CPB-K mice displayed a significantly higher ASR and a significantly lower magnitude of PPI as compared to BALB/cJ mice. The test-retest reliability was approved for PPI in both mouse strains, which was performed in repeated sessions over 13 weeks. In summary, our working hypothesis was confirmed that lower levels of hippocampal NMDA receptor densities correspond to lower sensorimotor gating in CPB-K mice. Based on this finding, further experiments using different behavioral paradigms have to be carried out to establish the CPB-K mouse strain as an animal model of schizophrenia.
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Authors
Rainer Wolf, Henrik Dobrowolny, Kay Matzke, Katrin Paelchen, Bernhard Bogerts, Herbert Schwegler,