Firing patterns of maternal rat prelimbic neurons during spontaneous contact with pups

Extracellular single unit activity was recorded from medial prefrontal cortex (mPFC) of postpartum dams over the course of 3 days while they engaged in spontaneous pup-directed behaviors and non-specific exploratory behavior. Out of 109 units identified over the course of the experiment, 15 units were observed to be pup-responsive and 15 increased their discharge rates non-specifically while not attending to pups. An association between neuronal activity and typical maternal behaviors (e.g., retrieval, pup-grooming, nursing) was not observed. Instead, brief bouts of snout contact with pups were accompanied by phasic increases and decreases in spike rates. The observed pup contact responsive cells might play a role in processing of sensory feedback from pups or the transmission of modulatory output to other subcortical maternal brain areas.

► First study to register from medial prefrontal neurons of behaving maternal rats. ► Shows relation between direct interactions with pups and increased neuronal firing. ► Pup responsive neurons were distinguished from those that were not pup responsive. ► Implicates prefrontal neurons in maternal goal-directed behavior.