Perspectives of zebrafish models of epilepsy: What, how and where next?

Epilepsy is a complex brain disorder with multiple underlying causes and poorly understood pathogenetic mechanisms. Animal models have been indispensable tools in experimental epilepsy research. Zebrafish (Danio rerio) are rapidly emerging as a promising model organism to study various brain disorders. Seizure-like behavioral and neurophysiological responses can be evoked in larval and adult zebrafish by various pharmacological and genetic manipulations, collectively emphasizing the growing utility of this model for studying epilepsy. Here, we discuss recent developments in using zebrafish models to study the seizure-like behavior involved in epilepsy, outlining current challenges and strategies for further translational research in this field.

► Recent developments in using zebrafish models to study epilepsy are discussed. ► Zebrafish seizure behavior is producible by pharmacological and genetic manipulations. ► Zebrafish offer opportunities to identify and validate biomarkers of epilepsy. ► Zebrafish are useful in screening novel antiepileptic drugs. ► Bioinformatic and biotechnology tools provide further insight into epileptogenesis.