C9ORF72-ALS/FTD: Transgenic Mice Make a Come-BAC

For five years, since the landmark discovery of the C9ORF72 hexanucleotide repeat expansion in ALS/FTD, a transgenic mouse model has remained elusive. Now, two laboratories ( Liu et al., 2016 and Jiang et al., 2016) report the development of BAC transgenic mice that recapitulate features of the human disease.