| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4321317 | Neuron | 2013 | 7 Pages |
•Genetic silencing of synaptic transmission in single neurons in vivo•Cell-autonomous role of excitatory synaptic transmission in individual neurons•Dichotomic role of synaptic transmission in neuronal structure and function•Synaptic excitation is not essential for spine development and maintenance
SummaryThe cell-autonomous role of synaptic transmission in the regulation of neuronal structural and electrical properties is unclear. We have now employed a genetic approach to eliminate glutamatergic synaptic transmission onto individual CA1 pyramidal neurons in a mosaic fashion in vivo. Surprisingly, while electrical properties are profoundly affected in these neurons, as well as inhibitory synaptic transmission, we found little perturbation of neuronal morphology, demonstrating a functional segregation of excitatory synaptic transmission from neuronal morphological development.
