Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4321487 | Neuron | 2012 | 10 Pages |
Abstract
Epigenetic processes, such as histone modifications and DNA methylation, have been associated with many neural functions including synaptic plasticity, learning, and memory. Here, we critically examine emerging evidence linking epigenetic mechanisms to the development or maintenance of chronic pain states. Although in its infancy, research in this area potentially unifies several pathophysiological processes underpinning abnormal pain processing and opens up a different avenue for the development of novel analgesics.
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Authors
Franziska Denk, Stephen B. McMahon,