The Ascent of Channels with Memory

One of the great mysteries of neuroscience is why neurons express so many different types of ion channels with such wide-ranging expression heterogeneity. In this issue of Neuron, Garden and colleagues add a new piece to this puzzle by demonstrating that the “memory” of various functional maps in regions of the medial entorhinal cortex resides in conductance gradients of two types of ion channels expressed in layer II stellate neurons.