Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4322776 | Neuron | 2007 | 10 Pages |
Abstract
Recent evidence supports the hypothesis of a functional dichotomy of perisomatic inhibition in the cerebral cortex: the parvalbumin- and cholecystokinin-containing basket cells that are specialized to control rhythm (as a clockwork) and “mood” (as a fine-tuning device), respectively, of network oscillations. Pathology extends this conclusion further, as the former is implicated in epilepsy and the latter in anxiety. The well-balanced cooperation of the two inhibitory systems is required for the normal network operations underlying the cognitive functions of the cerebral cortex.
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Authors
Tamás F. Freund, István Katona,