Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4322810 | Neuron | 2006 | 5 Pages |
Abstract
Arc/Arg3.1 is an effector immediate-early gene implicated in the consolidation of memories. Although cloned a decade ago, the physiological role of Arc/Arg3.1 in the brain has remained elusive. Four papers in this issue of Neuron address this function. These studies show that Arc/Arg3.1 regulates endophilin 3 and dynamin 2, two components of the endocytosis machinery. Genetic ablation of Arc/Arg3.1 in mice or overexpression in culture suggest that Arc/Arg3.1 regulates AMPA receptor trafficking and synaptic plasticity. Finally, Arc/Arg3.1 knockout mice show memory retention deficits. These recent developments provide new insights into the function of this popular activity-dependent neuronal marker.
Related Topics
Life Sciences
Neuroscience
Cellular and Molecular Neuroscience
Authors
Anastassios V. Tzingounis, Roger A. Nicoll,