Brain metabolism as a modulator of autophagy in neurodegeneration

•Autophagy is associated with metabolism and neurodegeneration.•Hormones and nutrients regulate autophagy in the brain.•Brain metabolism and autophagy change in the pathogenesis of neurodegeneration.

Emerging evidence that autophagy serves as a sweeper for toxic materials in the brain gives us new insight into the pathophysiology of neurodegenerative diseases. Autophagy is important for maintaining cellular homeostasis associated with metabolism. Some neurodegenerative diseases such as Alzheimer׳s and Parkinson׳s diseases are accompanied by altered metabolism and autophagy in the brain. In this review, we discuss how hormones and nutrients regulate autophagy in the brain and affect neurodegeneration.This article is part of a Special Issue entitled SI:Autophagy.