Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4324190 | Brain Research | 2014 | 9 Pages |
Abstract
Using 11.7Â T ultra high-field T2-weighted MRI, the present study aimed to investigate pathological changes of primary and secondary trigeminal pathways following neonatal transection of infraorbital nerve in rats. The trigeminal pathways consist of spinal trigeminal tract, trigeminal sensory nuclear complex, medial lemniscus, ventromedial portion of external medullary lamina and ventral posterior nucleus of thalamus. By selecting optimum parameters of MRI such as repetition time, echo time, and slice orientation, this study visualized the trigeminal pathways in rats without any contrast agents. Pathological changes due to the nerve transection were found at 8 weeks of age as a marked reduction of the areas of the trigeminal pathways connecting from the injured nerve. In addition, T2-weighted MR images of the trigeminal nerve trunk and the spinal trigeminal tract suggest a communication of CSF through the trigeminal nerve between the inside and outside of the brain stem. These results support the utility of ultra high-field MRI system for noninvasive assessment of effects of trigeminal nerve injury upon the trigeminal pathways.
Keywords
STRSPFPCpostnatal day 10Pr5P10EMLVPLCBCVPMCBMGd-DTPASpinal trigeminal tractPyramidal tractCritical periodpostnatal day 0longitudinal relaxation timetransverse relaxation timeecho timeRepetition timeInfraorbital nerveFacial nervemaxillary nerveMandibular nerveOphthalmic nerveCerebellar cortexexternal medullary laminamedial lemniscusCerebrospinal fluidCSFThalamic reticular nucleusinternal capsuletrigeminal ganglionIon
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Authors
Yasuhiro Ooi, Chizuko Inui-Yamamoto, Takashi Suzuki, Hiromichi Nakadate, Yoshitaka Nagase, Akitoshi Seiyama, Yoshichika Yoshioka, Junji Seki,