| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4324820 | Brain Research | 2013 | 29 Pages |
Abstract
⺠Tinnitus is exacerbated by stress and involves cochlear NMDA receptors. ⺠Dynorphins and salicylates potentiate glutamate effects at cochlear NMDA receptors. ⺠Salicylate produces tinnitus; dynorphins exist in the cochlea. ⺠Dynorphins released during periods of stress could exacerbate tinnitus. ⺠Opioid antagonism may alleviate a stress induced exacerbation of tinnitus.
Keywords
ACTHIntracochleari.v.α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acidCOX-2N-methyl-d-aspartateNMDALSOESASPLDBAAMPAStressIntravenousCNSdecibelDynorphinslateral superior oliveSound pressure levelGlutamate excitotoxicitySOCcentral nervous systemCyclooxygenase-2superior olivary complexi.c.Nor-BNINor-binaltorphimineadrenocorticotropic hormoneTinnitusCaPNMDA receptors
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Authors
Tony L. Sahley, Michael D. Hammonds, Frank E. Musiek,