Neuropeptide FF analog RF9 is not an antagonist of NPFF receptor and decreases food intake in mice after its central and peripheral administration

Article ID	Journal	Published Year	Pages	File Type
4324835	Brain Research	2013	8 Pages	PDF

Abstract

âº Binding of RF9 to NPFF2 receptor was confirmed. âº RF9 did not reverse phosphorylation of MAPK/ERK1/2 stimulated with [Tyr1]NPFF. âº RF9 did not inhibit anorexigenic effect of [Tyr1]NPFF. âº RF9 exhibited anorexigenic effect in mice after central and peripheral administration. âº This doubts an image that RF9 acts as a NPFF antagonist.

Keywords

NPFF RF9 PrRP Binding food intake

Related Topics

Life Sciences Neuroscience Neuroscience (General)

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Neuropeptide FF analog RF9 is not an antagonist of NPFF receptor and decreases food intake in mice after its central and peripheral administration

Authors

Lenka MaletÃnská, AneÅ¾ka Tichá, Veronika Nagelová, Andrea Å polcová, Miroslava Blechová, TomáÅ¡ Elbert, Blanka Å½elezná,