| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4325265 | Brain Research | 2012 | 13 Pages |
Malignant neuroblastomas are childhood tumors that remain mostly incurable. We explored efficacy of N-(4-hydroxyphenyl) retinamide (4-HPR) and (−)-epigallocatechin-3-gallate (EGCG) in altering expression of oncogenic microRNAs (OGmiRs) and tumor suppressor miRs (TSmiRs) for controlling growth of human malignant neuroblastoma SK-N-BE2 and IMR-32 cells. Combination of 4-HPR and EGCG most significantly decreased expression of OGmiRs (miR-92, miR-93, and miR-106b) and increased expression of TSmiRs (miR-7-1, miR-34a, and miR-99a) in both cell lines. Overexpression of miR-93 and miR-7-1, respectively, decreased and increased efficacy of treatments. Thus, alterations in expression of specific OGmiRs and TSmiRs by 4-HPR and EGCG inhibited growth of malignant neuroblastomas.
► Combination of 4-HPR and EGCG for treatment of neuroblastoma. ► Combination therapy altered expression of specific miRs in neuroblastoma. ► Overexpression of oncogenic miR-93 decreased efficacy of combination therapy. ► Overexpression of tumor suppressor miR-7-1 boosted efficacy of combination therapy.
