| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4325325 | Brain Research | 2012 | 11 Pages |
Abstract
⺠Improvement of bioenergetic efficiency may ameliorate mitochondrial damage. ⺠Mitochondrial damage is a hallmark of chronic neurodegenerative disorders, including ALS. ⺠Dexpramipexole (DEX) is a drug undergoing clinical trials in ALS. ⺠DEX inhibited stress- or injury-induced neuronal mitochondrial conductance. ⺠DEX reduced oxygen consumption while maintaining or increasing ATP levels.
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Neuroscience
Neuroscience (General)
Authors
Kambiz N. Alavian, Steven I. Dworetzky, Laura Bonanni, Ping Zhang, Silvio Sacchetti, Maria A. Mariggio, Marco Onofrj, Astrid Thomas, Hongmei Li, Jamie E. Mangold, Armando P. Signore, Ulrike DeMarco, Damon R. Demady, Panah Nabili, Emma Lazrove,