| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4325343 | Brain Research | 2012 | 8 Pages |
Abstract
⺠This work shows mechanism of Mg2+ block of purinergic stimulated Ca2+ responses in THP-1 cells. ⺠The P2X7R agonist BzATP activates metabotropic P2YR and ionotropic P2X7R. ⺠Elevated Mg2+ blocks Ca2+ influx through P2X7R and store operated channels (SOC). ⺠A model is proposed linking Mg2+ modulation of Ca2+ entry with neuroprotection.
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Authors
Nattinee Jantaratnotai, Patrick L. McGeer, James G. McLarnon,