| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4325508 | Brain Research | 2012 | 10 Pages |
Abstract
⺠The neuroprotective effect of ibudilast on ischemic stroke remains undetermined. ⺠Ibudilast suppressed cerebral infarction, edema, atrophy and apoptosis. ⺠It also significantly reduced mortality and improved neurological outcomes. ⺠It arrested the expression of inflammatory mediator molecules in ischemic brain. ⺠Ibudilast can exert beneficial effects on acute ischemic stroke.
Keywords
ICAECART-PCRPDECCATTCCBFMCAO2,3,5-triphenyl tetrazolium chloridemiddle cerebral artery occlusionInfarctioncerebral blood flowIschemic strokeexternal carotid arteryinternal carotid arterycommon carotid arteryAnti-inflammationPhosphodiesteraseNeuroprotectionPhosphodiesterase inhibitorReverse transcriptase-polymerase chain reaction
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Authors
Joo-Yong Lee, Eunsil Cho, Young Eun Ko, Inki Kim, Kyung Jin Lee, Sun U. Kwon, Dong-Wha Kang, Jong S. Kim,