Article ID Journal Published Year Pages File Type
4326158 Brain Research 2011 8 Pages PDF
Abstract
► Striatal carotid body grafts improve parkinsonism in animal models and in patients. ► GDNF contained in carotid body cells can be transported to nigral neurons. ► One year after graft, MPTP monkeys show motor recovery and increased 18F-DOPA uptake. ► The number of TH-GDNF immunoreactive nigral neurons is also increased. ► Carotid body graft might exert neuroprotective effect on spared dopaminergic neurons.
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