| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4326158 | Brain Research | 2011 | 8 Pages |
Abstract
⺠Striatal carotid body grafts improve parkinsonism in animal models and in patients. ⺠GDNF contained in carotid body cells can be transported to nigral neurons. ⺠One year after graft, MPTP monkeys show motor recovery and increased 18F-DOPA uptake. ⺠The number of TH-GDNF immunoreactive nigral neurons is also increased. ⺠Carotid body graft might exert neuroprotective effect on spared dopaminergic neurons.
Keywords
tyrosine hydroxylase-immunoreactiveCBCADAergicMacaca fascicularis18F-DOPAMPTPGDNFTH-ir1-methyl-4-phenyl-1,2,3,6-tetrahydropyridineSNpcParkinson's diseasesubstantia nigra pars compactaPositron emission tomographycarotid bodyDopamineDopaminergicGlial cell line-derived neurotrophic factorNeuroprotectionPET
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Authors
M.R. Luquin, M. Manrique, J. Guillén, J. Arbizu, C. Ordoñez, I. Marcilla,