Article ID Journal Published Year Pages File Type
4326965 Brain Research 2010 5 Pages PDF
Abstract

14-3-3 proteins comprise a large family of highly conserved, acidic polypeptides, expressed in all eukaryotic organisms, with highest concentration found in the brain. Multiple isoforms of 14-3-3 proteins have been shown to play an essential role in regulating differentiation, proliferation and transformation. In the previous study, the expression levels of all seven 14-3-3 isoforms were examined in astrocytoma. However, the expression of seven 14-3-3 isoforms in meningioma still remains unknown. This study is the first examination of 14-3-3 isoforms in three grades of meningioma by immunohistochemistry. 14-3-3ε, ζ and θ were specifically expressed in meningioma, and their expression levels increased with the increase of pathological grade of meningioma. The 14-3-3 η, β, γ and σ isoforms were negatively expressed in meningioma. In conclusion, The 14-3-3 ε, ζ and θ may be involved in tumorigenesis of meningioma and be efficient markers for predicting the degree of malignancy in meningioma.

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