| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4329774 | Brain Research | 2008 | 5 Pages |
Abstract
Modafinil is a well-known psychoactive drug used to treat narcolepsy, hypoglycemia, cerebral ischemia and Parkinson's disease. Previous studies showed that ATP-sensitive potassium channels (KATP) play a key role in response to cerebral ischemia, hypoglycemia or metabolic inhibition. Modafinil (0.01-1 mM) dose-dependently decreased the GABA-activated currents (IGABA). Pretreatment with the KATP channel blocker, glibenclamide (10 μM), significantly reduced the decrease of IGABA caused by modafinil. Thus, the inhibitory effect of modafinil on the IGABA is indirect by modulating KATP channel activation, at least in part mediated by KATP channel.
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Authors
Qing Huang, Ling Zhang, Hui Tang, Liecheng Wang, Yuanyin Wang,