Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4330245 | Brain Research | 2007 | 10 Pages |
Abstract
The potent neuroprotective activities of neurotrophic factors, including insulin-like growth factor 1 (IGF-1), make them promising candidates for treatment of amyotrophic lateral sclerosis (ALS). In an effort to maximize rate of motor neuron transduction, achieve high levels of spinal IGF-1 and thus enhance therapeutic benefit, we injected an adeno-associated virus 2 (AAV2)-based vector encoding human IGF-1 (CERE-130) into lumbar spinal cord parenchyma of SOD1G93A mice. We observed robust and long-term intraspinal IGF-1 expression and partial rescue of lumbar spinal cord motor neurons, as well as sex-specific delayed disease onset, weight loss, decline in hindlimb grip strength and increased animal survival.
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Neuroscience
Neuroscience (General)
Authors
Angelo C. Lepore, Christine Haenggeli, Mehdi Gasmi, Kathie M. Bishop, Raymond T. Bartus, Nicholas J. Maragakis, Jeffrey D. Rothstein,