Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4331187 | Brain Research | 2007 | 5 Pages |
Abstract
Insulin-like growth factors (IGFs) regulate cellular proliferation and death, and their bioactivity is controlled by IGF binding proteins (IGFBPs). Since IGFBP-2 is the major brain resident IGFBP, and we have demonstrated lithium-mediated changes in its mRNA and protein levels in neuronal cultures, we examined IGFBP-2 expression in prefrontal cortex postmortem brain tissue from subjects with mood disorders. We found decreased IGFBP-2 expression in bipolar disorder patients compared with controls; this was especially pronounced in subjects not treated with lithium. These results suggest a role for IGFBPs in the etiology and pharmacotherapy of mood disorders.
Keywords
Related Topics
Life Sciences
Neuroscience
Neuroscience (General)
Authors
Yarema B. Bezchlibnyk, Li Xu, Jun-Feng Wang, L. Trevor Young,