| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4331611 | Brain Research | 2007 | 6 Pages |
Abstract
We examined changes in the expression of Smad family members, which transduce signals from TGF-β superfamily ligands, following hypoglossal nerve injury. RT–PCR and in situ hybridization revealed that Smad1, 2, 3 and 4 mRNAs were significantly up-regulated in injured side, whereas Smad8 mRNA was down-regulated. Immunohistochemistry and Western blotting analysis confirmed the alterations of Smad1, 2 and 4 in injured neurons. These results suggest that the Smad signaling may be important for nerve regeneration.
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Authors
Noriko Okuyama, Sumiko Kiryu-Seo, Hiroshi Kiyama,