Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4331933 | Brain Research | 2006 | 4 Pages |
Abstract
Since many nuclear proteins are ectopically localized in the cytoplasm in the vulnerable neurons in Alzheimer disease (AD), we speculated that there is failure of the cytoplasmic-nuclear transport machinery in AD. In support of this notion, we found that importin α1, an essential component of cytoplasmic-nuclear transport, is abnormally accumulated in Hirano bodies in vulnerable hippocampal neurons in AD. These data suggest a hindrance in importin-mediated cytoplasmic-nuclear transport in AD.
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Authors
Hyoung-gon Lee, Masumi Ueda, Yoichi Miyamoto, Yoshihiro Yoneda, George Perry, Mark A. Smith, Xiongwei Zhu,