Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4332117 | Brain Research | 2006 | 4 Pages |
Abstract
We evaluated the effect of ebselen on human SH-SY5Y dopaminergic neuronal cells and determined whether ebselen, a glutathione peroxidase-mimetic, protected against MPTP-induced dopamine depletion in mice. Ebselen (10–100 μM) inhibited the proliferation of SH-SY5Y cells dose-dependently. Ebselen did not induce any behavioral changes and did not block MPTP-induced tremor and akinesia. Ebselen had no effect on the monoamine oxidase activity and did not protect against MPTP-induced dopamine depletion in striatum.
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Authors
Muralikrishnan Dhanasekaran, Subramaniam Uthayathas, Senthilkumar S. Karuppagounder, Kodeeswaran Parameshwaran, Vishnu Suppiramaniam, Manuchair Ebadi, Holly M. Brown-Borg,