Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4332333 | Brain Research | 2006 | 7 Pages |
Abstract
Methamphetamine (MA)-induced dopaminergic neurotoxicity is believed to be associated with the increased formation of free radicals. This study examined the effect of α-tocopherol (α-TC), a scavenger of reactive oxygen species, and deferoxamine (DFO), an iron chelator, on the MA-induced neurotoxicity. Male rats were treated with MA (10 mg/kg, every 2 h for four injections). The rat received either α-TC (20 mg/kg) intraperitoneally for 3 days and 30 min prior to MA administration or DFO (50 mg/kg) subcutaneously 30 min before MA administration. The concentrations of dopamine (DA), serotonin and their metabolites decreased significantly after MA administration, which was inhibited by the α-TC and DFO pretreatment. α-TC and DFO attenuated the MA-induced hyperthermia as well as the alterations in the locomotor activity. The level of lipid peroxidation was higher and the reduced glutathione concentration was lower in the MA-treated rats. These changes were significantly attenuated by α-TC and DFO. This suggests that α-TC and DFO ameliorate the MA-induced neuronal damage by decreasing the level of oxidative stress.
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Authors
Mee-Jung Park, Sang-Ki Lee, Mi-Ae Lim, Hee-Sun Chung, Sung-Ig Cho, Choon-Gon Jang, Sun-Mee Lee,