| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4332349 | Brain Research | 2006 | 6 Pages |
Abstract
To investigate the role of heme oxygenase (HO) isozymes, we used siRNA technology to suppress HO-1 expression. HO-1 siRNA-transfected HT22 cells were vulnerable to hydrogen peroxide- and 4-hydroxynonenal-induced cytotoxicity. Biliverdin and bilirubin, degradative products of heme catalyzed by HO, protected HT22 cells from the insult of these oxidative stressors. These results suggest that inducible HO-1 plays a protective role against oxidative stress in HT22 cells.
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Authors
Asuka Kaizaki, Sachiko Tanaka, Kumiko Ishige, Satoshi Numazawa, Takemi Yoshida,