Differential expression of mouse orexin receptor type-2 (OX2R) variants in the mouse brain

We have identified two novel mouse orexin type-2 receptor (OX2R) splice variants: OX2αR and OX2βR. Here, we have mapped in detail the differential gene expression of OX2αR and OX2βR in the mouse brain. Using RT-PCR and in situ hybridization, we show that OX2αR is expressed in various areas of the mouse brain and has low expression in caudal part of cerebellum. OX2βR is expressed in detectable levels, with the exception of striatum, midbrain and anterior part of cerebellum/pons. Our novel findings demonstrate the differential expression of OX2R splice variants in the mouse brain.