Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4332807 | Brain Research | 2006 | 6 Pages |
Abstract
Prolonged over-exposure of rats to corticosterone attenuates 5-HT1A-receptor-mediated responses in hippocampal CA1 cells through an unknown mechanism, not involving downregulation of 5-HT1A receptor expression. We here tested if corticosterone changes 5-HT1A receptor function indirectly, by altering hippocampal mRNA expression of NCAM, SGK1, or RGS4, which all modulate 5-HT1A receptor function. We found that the expression of none of these candidates was affected by corticosterone treatment.
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Authors
Neeltje G. van Gemert, Els van Riel, Onno C. Meijer, Susanne Fehr, Melitta Schachner, Marian Joëls,