Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4333055 | Brain Research | 2006 | 9 Pages |
Abstract
The effects of intraperitoneal (i.p.) administration of 2-buten-4-olide (2-B4O), an endogenous sugar acid, on the hypothalamo-neurohypophyseal system were examined in rats. Plasma oxytocin (OXT) levels were significantly increased 15-60Â min after i.p. administration of 2-B4O (100Â mg/kg), whereas plasma arginine vasopressin (AVP) did not change. Dual immunostaining revealed that Fos-like immunoreactivity (LI) was predominantly observed in OXT-secreting neurons in the paraventricular (PVN) and the supraoptic nuclei (SON) 120Â min after i.p. administration of 2-B4O. In addition, many Fos-LI neurons were observed in the nucleus of the tractus solitarius (NTS) after i.p. administration of 2-B4O. These results suggest that a peripherally administered high dose of 2-B4O activates OXT-secreting neurons in the hypothalamus through activation of NTS neurons, possibly as a result of a stress response.
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Authors
Makoto Kawasaki, Chiyo Yamaga, Tatsushi Onaka, Jun Saito, Takashi Mera, Hirofumi Hashimoto, Hiroaki Fujihara, Nobukazu Okimoto, Hideo Ohnishi, Toshitaka Nakamura, Yoichi Ueta,