Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4333409 | Brain Research | 2006 | 4 Pages |
Abstract
The present study examined the ability of antioxidant effects of angiotensin-converting enzyme (ACE) inhibitor, imidaprilat, on the synergistic effect of bisphenol A and 1-methyl-4-phenylpyridinium ion (MPP+)-induced hydroxyl radical (OH) formation and dopamine (DA) efflux in extracellular fluid of rat striatum. Bisphenol A clearly enhanced OH formation and DA efflux induced by MPP+. When imidaprilat was infused in bisphenol A and MPP+-treated rats, DA efflux and OH formation significantly decreased, as compared with that in the bisphenol A and MPP+ treated control. These results suggest that ACE inhibitors may protect against the synergistic effect of bisphenol A and MPP+-induced OH formation via suppressing DA efflux in the rat striatum.
Keywords
ACEMPTP1-methyl-4-phenylpyridinium ion1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine2,3-DHBA2,3-dihydroxybenzoic acidMPP+Angiotensin-converting enzymeBisphenol AParkinson's diseaseDopamineHydroxyl free radicalHydroxyl radicalangiotensin-converting enzyme inhibitorHPLChigh-performance liquid chromatography
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Authors
Toshio Obata,