Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4333850 | Brain Research Reviews | 2008 | 11 Pages |
Abstract
Rats deprived of social contact with other rats at a young age experience a form of prolonged stress that leads to long-lasting alteration in their behavior profile. This chronic stress paradigm is thus thought to be anxiogenic for these normally gregarious animals and their abnormal reactivity to environmental stimuli, when reared under this condition, is thought to be a product of prolonged stress. Neurochemical, molecular, and electrophysiological evidences demonstrate that social isolation is associated with alteration in the structure and function of GABAA receptors and suggest that endogenous content of the progesterone metabolite 3α,5α-TH PROG may be an important determinant in regulating brain excitability and sensitivity to stimuli and point out its possible role in psychiatric and neurological disorder.
Keywords
GHBγ-HydroxybutyratePBRACTHCRFminiature IPSCmIPSCIPSCEthanolNeuroactive steroidγ-aminobutyric acidSocial isolationinhibitory postsynaptic currentStarcorticotropin-releasing factorRatHPAadrenocorticotropic hormonehypothalamic–pituitary–adrenalSteroidogenic acute regulatory proteinGABAperipheral benzodiazepine receptor
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Authors
Mariangela Serra, Maria Giuseppina Pisu, Maria Cristina Mostallino, Enrico Sanna, Giovanni Biggio,