Article ID Journal Published Year Pages File Type
4333870 Brain Research Reviews 2008 5 Pages PDF
Abstract

In this review, we focus on the marked adaptability of dopamine D2 receptors to varying agonist levels and we discuss the extent to which this phenomenon can account for the heterogeneity of these receptors in regard to function and pharmacological responsiveness. We emphasize the significance of a distinction between synaptic and extrasynaptic receptors in this context. For example, the application of this dichotomy appears to shed new light on the various subgroups of antipsychotic drugs and the mechanisms underlying their different profiles.

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