Receptor mosaics of neural and immune communication: Possible implications for basal ganglia functions

Article ID	Journal	Published Year	Pages	File Type
4333872	Brain Research Reviews	2008	15 Pages	PDF

Abstract

Receptor assemblies seem to play a key role in the integration and modulation of molecular signals of cell-cell communications. This may be confirmed by recent discoveries of the immunological synapse and cytokine networks which can be also treated within a sort of meta-system-neuroimmune molecular network. On the examples of receptor superfamilies expressed both in the neural and immune cells, our review paper aims to show some implications of receptor-receptor interactions for basal ganglia functions in health and disease.

Keywords

EGF LPS PBMC MCP TCr SDF EPO SNC SST GBR MPTP GPCR SRBC PAMP TLR TGF GM-CSF PRR NKCC TH-ir IRAK1 TRAF6 PDGF HLA-DR IL-1 receptor associated kinase RAGE TAK1 NTR CR3 LRR EpoR OPR Mac1 SR-A1 TNF opioid peptide receptor Janus kinase G-protein coupled receptor ROS STAT Human leukocyte antigen HLA erythropoietin amyotrophic lateral sclerosis pathogen-associated molecular patterns AIDS Immunoglobuline interferon IFN cornu ammonis Alzheimer's disease ALS Parkinson's disease substantia nigra substantia nigra pars compacta leucine-rich repeat TIR Toll-like receptor HAD CNS HIV-associated dementia Dopaminergic Peripheral blood mononuclear cell Dendritic cell Age acquired immunodeficiency syndrome Somatostatin cytokine-induced neutrophil chemoattractant central nervous system Stromal cell-derived factor Granulocyte macrophage colony stimulating factor epidermal growth factor tumor growth factor nuclear factor TNF receptor-associated factor basal ganglia Superfamily platelet-derived growth factor tumor necrosis factor lipopolysaccharide Signal transducer and activator of transcription Advanced glycation endproducts Receptor Mosaic Multiple sclerosis neurotensin Synapse HIV human immunodeficiency virus methyl-accepting chemotaxis protein G-protein Amyloid-beta protein guanine nucleotide-binding protein monocyte chemoattractant protein CINC JAK Cannabinoid GABA sheep red blood cells Reactive oxygen species Toll/IL-1 receptor Erythropoietin Receptor receptor for AGE Complement receptor T-cell receptor PRR, Pattern recognition receptor