| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4334228 | Current Opinion in Neurobiology | 2011 | 9 Pages |
Abstract
⺠Largest genetic risk for late-onset Alzheimer's disease resides at the APOE gene. ⺠Innate immune response is consistently observed in AD and a possible contributor. ⺠apoE isoforms regulate multiple facets of innate immune response in brain. ⺠apoE isoforms may alter AD through both Aβ-dependent and Aβ-independent mechanisms.
Related Topics
Life Sciences
Neuroscience
Neuroscience (General)
Authors
C Dirk Keene, Eiron Cudaback, Xianwu Li, Kathleen S Montine, Thomas J Montine,