Clay (KSF and K10)-supported heteropoly acids: Friendly, efficient, reusable and heterogeneous catalysts for high yield synthesis of 1,5-benzodiazepine derivatives both in solution and under solvent-free conditions

A simple and versatile method for the synthesis of 1,5-benzodiazepines via condensation of 1,2-phenylenediamines and ketones in the presence of catalytic amount of clay-supported polyoxometalates (POMs) was described. The method is applicable to both cyclic and acyclic ketones without significant differences. The reaction proceeds efficiently under ambient conditions with good to excellent yields.

Graphical abstractA simple and versatile method for the synthesis of 1,5-benzodiazepines via condensation of 1,2-phenylenediamines and ketones in the presence of catalytic amount of clay-supported polyoxometalates (POMs) was described. The method is applicable to both cyclic and acyclic ketones without significant differences. The reaction proceeds efficiently under ambient conditions with good to excellent yields.Figure optionsDownload full-size imageDownload as PowerPoint slide