| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4334808 | Current Opinion in Neurobiology | 2006 | 7 Pages |
Abstract
Homer proteins regulate signal transduction, synaptogenesis and receptor trafficking, in addition to maintaining and regulating extracellular glutamate levels in limbo–corticostriatal brain regions. Converging preclinical observations indicate a potential role for both immediate early gene Homer isoforms and constitutively expressed Homer isoforms in behavioral pathologies associated with neuropsychiatric disorders, such as addiction and/or alcoholism, depression, anxiety, epilepsy and schizophrenia.
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Authors
Karen K Szumlinski, Peter W Kalivas, Paul F Worley,