| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4335078 | Journal of Neuroscience Methods | 2012 | 7 Pages |
Abstract
⺠This paper describes a new light-weight wireless implantable micro stimulator device for mice. ⺠The device delivers biphasic pulse patterns to two individual electrode pairs, mimicking the clinical situation. ⺠Bench-top validation shows that this device reliably delivers continuous bilateral stimulation. ⺠In vivo implementation indicates that the wireless implantable stimulator in mice does not restrict the animal's mobility and hygiene (grooming behavior). ⺠As previously shown by others, our in vivo results showed a marked increase in c-fos expression around the electrode tip in the nucleus accumbens in mice following DBS at 100 μA.
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Authors
Ria de Haas, Rolf Struikmans, Geoffrey van der Plasse, Linda van Kerkhof, Jan H. Brakkee, Martien J.H. Kas, Herman G.M. Westenberg,