| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4335132 | Journal of Neuroscience Methods | 2012 | 10 Pages |
Abstract
⺠We developed a score that predicts death in the SMNÎ7 mouse model of SMA. ⺠We showed that SMNÎ7 mice has increased tissue lactate and decrease in respiratory rate. ⺠The novel score correlates linearly with tissue lactate levels and respiratory rate. ⺠This work provides insight into the disease stage and a possible biomarker for SMA. ⺠This method has broad application to various neonatal animal models of neurological disorders.
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Authors
Bassem F. El-Khodor, Kim Cirillo, Jose A. Beltran, Richard Mushlin, Margaret L. Winberg, Rachel Charney, Olga Chomicova, Tara Marino, Sylvie Ramboz,