Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4335365 | Journal of Neuroscience Methods | 2011 | 6 Pages |
Abstract
⺠The occurrence of seizures is a rare event generated by a dysfunction of neuronal activity in the epileptogenic region. ⺠The dysfunctional regulation alters endogenous electric field, changes relevant characteristics of charge dynamics and leads to seizure generation. ⺠The transition is generated in absence of neuronal activity, low firing rate in epileptogenic region that maintains chaotic dynamic regime. ⺠The alteration in regulation can be modeled by perturbed Hamiltonian systems with many degrees of freedom. ⺠Kolmogorov Arnold Moser (KAM) theory and its extensions can provide a physical model of transition to seizure. ⺠Understanding the physical mechanism is required to predict, stop an imminent seizure and to provide an adequate treatment by neuromodulation.
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Authors
Dorian Aur,