Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4335950 | Journal of Neuroscience Methods | 2008 | 8 Pages |
Abstract
Peripheral nerve grafts have shown the ability to facilitate central axonal growth and regenerate the adult central nervous system. However, the detailed description of a technique for atraumatic graft placement within the brain is lacking. We present a stereotactic procedure to implant a peripheral nerve graft within a rat's brain with minimal brain tissue damage. The procedure permits a correct graft placement joining two chosen points, and the survival and integration of the graft in the host tissue with a light glial reaction, with evidence of central axonal growth inside the graft, at least up to 8 weeks after its implantation.
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Authors
Ulises Gómez-Pinedo, M. Carmen Félez, Francisco J. Sancho-Bielsa, Sandra Vidueira, Carmen Cabanes, Mario Soriano, José M. García-Verdugo, Juan A. Barcia,